The Role of MicroRNAs in Treg-Derived Extracellular Vesicles: A Narrative Review Focusing on Immune-Related Diseases - PubMed
5 hours ago
- #immune-regulation
- #miRNAs
- #Treg-EVs
- Regulatory T cells (Tregs) are key immunosuppressive cells involved in immune-related diseases.
- Treg-derived extracellular vesicles (Treg-EVs) facilitate cell-to-cell communication and immune regulation by transferring molecules like microRNAs (miRNAs).
- miRNAs are small non-coding RNAs that regulate gene expression post-transcription by binding to target mRNAs.
- The review explores the roles of miRNAs within Treg-EVs in conditions such as rheumatoid arthritis, inflammatory bowel disease, autoimmune vasculitis, multiple sclerosis, and transplant settings.
- Treg-EVs can deliver miRNAs to specific immune cells, promoting immunosuppression and potentially treating immune-related diseases.