IL-22 mediated immuno-vascular crosstalk aggravates Ang II induced hypertension in mice via ferritinophagy2 - PubMed
5 hours ago
- #Ferroptosis
- #Vascular Remodeling
- #IL-22
- AHR antagonist CH-223191 alleviates Ang II-induced hypertension and vascular remodeling in mice.
- AHR inhibition reduces Th22 differentiation and IL-22/STAT3 signaling, decreasing oxidative stress and ferritinophagy in VSMCs.
- Th22 cell transfer worsens vascular remodeling; ferroptosis inhibitor Ferrostatin-1 mimics AHR antagonist's protective effects.