The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis - PubMed
5 hours ago
- #γ-tubulin
- #psoriasis
- #parkin
- Psoriasis is linked to Parkinson's disease (PD) through the parkin-γ-tubulin axis.
- Parkin levels are reduced in psoriatic skin in both clinical samples and mouse models.
- Parkin-deficient mice show epidermal hyperplasia, increased keratinocyte proliferation, and higher psoriasis susceptibility.
- Parkin interacts with γ-tubulin, mediating its ubiquitination and proteasomal degradation.
- Reduced parkin in psoriatic skin causes γ-tubulin accumulation, disrupting microtubule organization and leading to keratinocyte hyperproliferation.
- The findings highlight parkin's role in epidermal physiology and the crosstalk between psoriasis and PD.