Role of broad in intestinal stem cells of adult Drosophila - PubMed
6 hours ago
- #Jak/STAT signaling
- #Broad gene
- #Intestinal stem cells
- Broad (br) is essential for maintaining intestinal stem cells (ISCs) and repairing intestinal injury in adult Drosophila melanogaster.
- It regulates both proliferation and differentiation of ISCs; knockdown impairs differentiation into enterocytes (ECs), while overexpression promotes it.
- Br knockdown reduces Jak/STAT signaling activity in ISCs, and upregulating Jak/STAT or EGFR signaling rescues the phenotype.
- Br likely regulates ISC proliferation and differentiation through Jak/STAT and EGFR signaling pathways.