Chromatin regulators TOP2A and PPARGC1A stratify prostate cancer risk and reveal TOP2A-driven progression via PI3K/AKT pathway - PubMed
5 hours ago
- #chromatin regulators
- #PI3K/AKT pathway
- #prostate cancer
- Chromatin regulators TOP2A and PPARGC1A help stratify prostate cancer risk and progression.
- TOP2A-driven progression in prostate cancer occurs via the PI3K/AKT pathway.
- Molecular subtypes and risk scores based on TOP2A and PPARGC1A predict biochemical recurrence post-radical prostatectomy.
- Cluster 2, defined by TOP2A and PPARGC1A, shows shorter biochemical recurrence-free survival across multiple datasets.
- TOP2A knockdown reduces prostate cancer cell proliferation, migration, and invasion by suppressing PI3K/AKT pathway activation.