Restoration of RBM22 overcomes the transcriptional and epigenetic barriers of cardiomyocyte proliferation for heart regeneration - PubMed
3 days ago
- #Epigenetics
- #Cardiac Regeneration
- #RBM22
- RBM22 is identified as a key regulator of cardiomyocyte proliferation.
- Deletion of Rbm22 in cardiomyocytes impairs neonatal heart regeneration and worsens post-infarction remodeling in adult mice.
- RBM22 binds to promoters of cell cycle genes (Cdk4, Ccna2, Ccne1) and collaborates with SMARCA4 to enhance transcriptional accessibility.
- RBM22 is crucial for recruiting RNA Polymerase II to specific gene loci to drive transcription.
- AAV9-mediated delivery of Rbm22 promotes cardiomyocyte proliferation post-cardiac damage and in human induced pluripotent stem cell-derived cardiomyocytes.
- RBM22 acts as a transcriptional and epigenetic regulator, overcoming cell-cycle barriers in cardiomyocytes, offering therapeutic potential for cardiac injury.