Choroid plexus inflammation in bipolar disorder - PubMed
5 hours ago
- #choroid plexus
- #inflammation
- #bipolar disorder
- Inflammation is a key feature of bipolar disorder (BD) pathophysiology, with brain barriers playing a role in immune-brain interactions.
- The study found elevated levels of cytokines CCL2 and SPP1 in postmortem choroid plexus tissue from BD individuals, linked to monocyte and macrophage activity.
- Reduced expression of cytokines involved in homeostasis, trophic support, and immune signaling (e.g., OSM, IGF-1, BDNF) was observed in BD.
- Bulk RNA sequencing showed upregulated genes related to oxidative stress, mitochondrial function, and immune regulation in BD, while the CSF biomarker NELL2 was downregulated.
- Gene set enrichment analysis indicated activation of inflammatory pathways and reduced junction-related gene expression, suggesting altered choroid plexus function in BD.
- The findings support the choroid plexus as a site of immune dysregulation in BD and highlight brain barrier dysfunction in mood disorders.