A MUC1-ALIX complex regulates extracellular vesicle cargo loading with activated SRC to enhance pancreatic cancer progression - PubMed
2 days ago
- #Pancreatic Cancer
- #MUC1-ALIX Interaction
- #Extracellular Vesicles
- MUC1 is highly enriched in EVs from pancreatic cancer cells and patient tumors, but not in normal pancreas.
- MUC1-positive EVs promote tumor cell growth, motility, invasion, and metastasis both in vitro and in vivo.
- MUC1 interacts with ALIX to influence EV biogenesis and selective loading of oncogenic cargo like PhosphoTyr416-Src.
- EVs from SRC inhibitor-treated cells show reduced effects on tumor cell viability, migration, and invasion.
- MUC1-positive EVs containing activated Src contribute to pancreatic cancer progression by enhancing tumor-specific EV cargo loading.