Ageing changes our genes – huge epigenetic atlas gives clearest picture yet
8 days ago
- #Epigenetics
- #DNA Methylation
- #Ageing
- The study provides a comprehensive analysis of DNA methylation changes across 17 human tissues throughout the adult lifespan.
- Findings reveal that some tissues, like the retina and stomach, age faster than others, such as the cervix or skin.
- Universal epigenetic markers of ageing were identified across different organs, aiding in understanding the link between DNA methylation and ageing.
- The research highlights specific genes, including HDAC4, HOX, and MEST, as strong biological markers of ageing across several tissues.
- High methylation of the PCDHG gene family was identified as a driver of the ageing process in multiple organs.
- The study's findings could help in identifying molecular targets for anti-ageing treatments.