Hh and EGFR-Ras signaling promote distinct steps of tumor progression in the Drosophila follicle epithelium - PubMed
5 hours ago
- #Signaling Pathways
- #Drosophila
- #Tumor Progression
- Hh and EGFR-Ras signaling pathways play distinct roles in tumor progression in the Drosophila follicle epithelium.
- Hedgehog signaling promotes both an undifferentiated state and differentiation via the transcription factor Zfh1, resembling partial epithelial-mesenchymal transition.
- EGFR-Ras overactivation causes cell cycle defects by activating Pointed and E2f1 transcription factors and blocks differentiation.
- Concurrent overactivation of both pathways leads to tumor-like growth, loss of tissue architecture, sustained proliferation, and reduced host lifespan.
- Single-cell transcriptomics and genetic analysis reveal how these pathways converge transcriptionally to prevent malignant behavior.