Atypical Tetracyclines Promote Longevity and Ferroptotic Neuroprotection via Translation Attenuation - PubMed
6 hours ago
- #translation inhibition
- #neuroprotection
- #longevity
- Tetracyclines, including atypical variants, attenuate protein translation independently of antibiotic activity and stress response activation.
- Atypical tetracyclines like 4-epiminocycline and 12-aminominocycline extend lifespan in C. elegans and protect neurons from ferroptotic stress.
- Pharmacological attenuation of translation is identified as a druggable mechanism to promote longevity and neuroprotection in mammals.