Single-cell Transcriptomics Reveals Cytotrophoblast Subtypes and Senescence in Recurrent Spontaneous Abortion - PubMed
7 hours ago
- #placental dysfunction
- #single-cell RNA sequencing
- #cellular senescence
- Recurrent spontaneous abortion (RSA) involves the loss of two or more pregnancies before 20 weeks of gestation.
- Single-cell RNA sequencing identified three cytotrophoblast (CTB) subtypes in RSA: CTB1 (protein synthesis), CTB2 (proliferative progenitor), and CTB3 (adhesive/invasive precursor to EVTs).
- Syncytiotrophoblasts (STBs) were characterized for hormone production, with impaired function in RSA.
- CTB2 and CTB3 in RSA exhibited cellular senescence, reducing proliferative and differentiation capacity.
- Aberrant trophoblast senescence may contribute to defective placentation in RSA, suggesting potential therapeutic targets.