Mechanobiology of inflammation: Pulling the strings of innate immunity - PubMed
5 hours ago
- #Inflammation
- #Innate Immunity
- #Mechanobiology
- Mechanical forces like stretch, stiffness, and shear stress regulate innate immune responses.
- Forces engage mechanotransduction pathways, modulating immune programs, remodeling tissues, and directing leukocyte traffic.
- Chronically perturbed tissue mechanics drive pathological inflammation in diseases such as asthma, arthritis, fibrosis, and atherosclerosis.
- Mechano-inflammation is a framework linking physical forces to immune regulation, with diagnostic and therapeutic potential.