Polystyrene-nanoplastics-induced unfolded protein response in monocyte-derived macrophages mediates pulmonary fibrosis via oxidative-stress-dependent IL-6 secretion - PubMed
7 hours ago
- #IL-6
- #nanoplastics
- #pulmonary fibrosis
- Polystyrene nanoplastics (PS-NPs) induce pulmonary fibrosis through macrophage activation.
- PS-NPs trigger unfolded protein response (UPR) in monocyte-derived macrophages (MoMs).
- UPR activation leads to oxidative-stress-dependent IL-6 secretion in MoMs.
- IL-6 secretion promotes fibroblast-to-myofibroblast differentiation, driving fibrosis.
- The PERK arm of UPR is the predominant pathway involved.
- IL-6 deficiency or neutralization reduces PS-NP-induced lung inflammation and fibrosis.
- Resolvin D1 mitigates fibrosis by reducing inflammation and cytokine secretion.
- Findings suggest IL-6 as a therapeutic target for fibrotic lung diseases.