Downregulating Platelet Endothelial Cell Adhesion Molecule-1 Enhances Learning and Memory and Alleviates Hallmark Pathologies in Alzheimer's Disease - PubMed
2 days ago
- #Alzheimer's Disease
- #CD31
- #Neuroinflammation
- Elevated levels of CD31 (PECAM1) were found in the brains of Alzheimer's disease (AD) patients and AD transgenic mice.
- Systemic knockdown of CD31 in 5xFAD mice improved cognitive functions and reduced AD pathologies like β-amyloid precipitation and tau hyperphosphorylation.
- CD31 knockdown also alleviated neuroinflammation by reducing microglial activation and pro-inflammatory cytokine expression.
- Transcriptomic analysis showed CD31 knockdown rectified imbalanced gene expression related to AD.
- Mechanistically, CD31 knockdown suppressed STAT1 and IRF1 expression by reducing histone lactylation at H3K14 and H4K12.
- CD31 is identified as a promising therapeutic target for AD.