Comparative effectiveness and safety of pharmacological treatments for rapid tranquilisation in emergency settings: a systematic review and individual participant data network meta-analysis - PubMed
6 hours ago
- #rapid tranquilisation
- #network meta-analysis
- #psychomotor agitation
- This study is a systematic review and individual participant data network meta-analysis comparing pharmacological treatments for rapid tranquilisation in emergency settings.
- In moderate agitation, antipsychotic-benzodiazepine combinations, benzodiazepines alone, and other antipsychotics showed higher odds of sedation compared to haloperidol monotherapy.
- In severe agitation, antipsychotic-benzodiazepine combinations were more effective than haloperidol, while benzodiazepines alone and other antipsychotics had uncertain effectiveness.
- Haloperidol monotherapy was associated with a higher risk of extrapyramidal side-effects, and benzodiazepines (alone or in combination) with hypotension.
- Confidence in these estimates was very low due to imprecision and heterogeneity, highlighting the need for large trials for more precise recommendations.