Enhancing antitumour nanovaccine efficacy via integrated cholesterol modulation in situ - PubMed
5 hours ago
- #dendritic cells
- #antitumour nanovaccine
- #cholesterol modulation
- Manipulating cholesterol levels in dendritic cell (DC) membranes enhances antigen presentation capability.
- A membrane-cholesterol-depleting nanovaccine was developed to deliver antigens to DCs while reducing membrane cholesterol.
- Cholesterol deprivation increased contact frequency between DCs and T cells and reshaped the tumor immune microenvironment.
- The nanovaccine promoted immune synapse formation with CD8+ T cells, boosting T cell activation and proliferation.
- Mechanisms involve remodeling cholesterol microdomains in DC membranes and blocking efferocytosis pathways.
- This approach inhibits tumorigenesis and progression in multiple tumor models, enhancing vaccine efficacy.