Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury - PubMed
5 hours ago
- #Spinal cord injury
- #BDNF mRNA
- #Extracellular vesicles
- Engineered extracellular vesicles (EVs) target integrin αvβ8 and deliver BDNF mRNA for spinal cord injury (SCI) treatment.
- The mBDNF@αITGEV construct maintains EV identity and morphology, showing efficient targeting and cargo delivery.
- In neuron-microglia co-culture, mBDNF@αITGEV reduces pro-inflammatory cytokines (TNF-α, IL-1β) and increases anti-inflammatory cytokines (IL-4, IL-10).
- The therapy promotes motor recovery by modulating inflammation and inhibiting neuronal ferroptosis.
- BDNF mRNA delivery enhances GPX4 expression and stabilizes mitochondrial dynamics, reducing oxidative damage.
- Provides a non-invasive, systemic EV-mRNA therapeutic strategy with translational potential for SCI.