Integrated bioinformatics and mendelian randomization reveal a six-gene diagnostic signature and key role of CYP26B1 in sarcopenia - PubMed
5 hours ago
- #sarcopenia
- #bioinformatics
- #diagnostic biomarkers
- Integrated bioinformatics and Mendelian randomization identified a six-gene diagnostic signature for sarcopenia.
- The study found 318 differentially expressed genes (DEGs) and narrowed down to 109 potential biomarkers related to immune regulation, muscle cytoskeleton, and retinol metabolism.
- A six-gene diagnostic model (FOXO1, ZBTB16, HOXB2, LYVE1, MGP, and CYP26B1) was developed with high predictive accuracy (AUC >0.80).
- Mendelian randomization confirmed CYP26B1 as the sole causal gene linked to sarcopenia, highlighting its role in retinoic acid metabolism.
- The findings provide a robust diagnostic model and therapeutic target, offering new avenues for early diagnosis and precision therapy.