BCR ligation selectively inhibits IgE class switch recombination - PubMed
5 hours ago
- #allergic disease
- #BCR signaling
- #IgE regulation
- BCR signaling strength inversely correlates with IgE-switched germinal center B cells and plasma cells in immunized mice.
- In mouse B cells, BCR ligation inhibits IgE class switch recombination (CSR) based on ligand concentration, affinity, and avidity, dependent on Syk but not PI3K.
- Cytokines IL-21 and TGFβ1 cooperate with BCR signaling to further inhibit IgE CSR.
- Similar inhibition of IgE CSR by BCR signaling is observed in human tonsillar B cells.