Single-Atom Nanozyme Driven Lactate Reversal Fuels Oxidative Metabolism and Represses Lactylation to Heal Diabetic Wounds - PubMed
5 hours ago
- #metabolic reprogramming
- #nanozyme
- #diabetic wounds
- Single-cell RNA sequencing (scRNA-seq) analysis identified ROS and excessive lactate as key factors in chronic inflammation.
- Phosphorus-doped single-atom iron nanozyme (Fe@CN-P) was developed to enhance lactate oxidation.
- Phosphorus increases electron density at the iron center, improving proton-capture capacity and lowering energy barriers for lactate conversion to pyruvate.
- Fe@CN-P exhibits dual functions: lactate oxidation and ROS scavenging, restoring mitochondrial activity and establishing a 'reversal-reutilization' metabolic pathway.
- The nanozyme drives metabolic reprogramming and epigenetic remodeling to regulate inflammation, offering therapeutic potential for diabetic wounds.