Divergent ILC3 responses to PDGF-D control mucosal immunity - PubMed
5 hours ago
- #mucosal immunity
- #PDGF-D
- #ILC3
- PDGF-D acts as a noncanonical ligand for human NKp44+ group 3 innate lymphoid cells (ILC3s).
- Mice lack NKp44, but PDGF-D promotes IL-22 production and ILC3 proliferation via PDGFRβ.
- Mice lacking PDGFRβ in ILC3s were more susceptible to enteric infections.
- NKp44-transgenic mice showed PDGF-D engagement induced a type 1 effector program with TNF-α and IFN-γ production.
- Early IFN-γ release protected mice from infections, but sustained IFN-γ was harmful.
- Fibroblasts and endothelial cells were identified as inflammation-responsive PDGF-D sources.
- The study reveals divergent PDGF-D sensing mechanisms in ILC3s across species and their roles in mucosal immunity.