Risk factors for venous thromboembolism in newly diagnosed multiple myeloma patients based on thrombosis prophylaxis - PubMed
4 days ago
- #Venous Thromboembolism
- #Risk Factors
- #Multiple Myeloma
- Age is an independent risk factor for venous thromboembolism (VTE) in newly diagnosed multiple myeloma (NDMM) patients.
- Immobilization ≥ 72 hours significantly increases VTE risk.
- Elevated D-dimer (> 0.55 mg/L) is associated with higher VTE risk.
- Estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m² raises VTE risk.
- Doxorubicin and dexamethasone 160 mg/cyc combined with immunomodulators (IMiDs) are significant risk factors.
- Baseline anticoagulation and antiplatelet therapy serve as protective factors against VTE.
- Age modifies the effects of renal insufficiency and dexamethasone-IMiDs combination on VTE risk.
- Renal insufficiency poses a greater VTE risk in older patients.
- Dexamethasone-IMiDs combination increases VTE risk in younger patients but not significantly in older patients.