Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and Meta-Analysis - PubMed
3 months ago
- #food allergy
- #infants
- #meta-analysis
- The systematic review and meta-analysis analyzed 190 studies involving 2.8 million participants across 40 countries.
- Overall food allergy incidence in infants and children was estimated at 4.7% with moderate certainty.
- Strongest risk factors included prior allergic conditions (e.g., atopic dermatitis, allergic rhinitis, wheeze), severity of atopic dermatitis, increased skin transepidermal water loss, and filaggrin gene variations.
- Other significant risk factors were delayed solid food introduction, infant antibiotic use, male sex, firstborn child, family history of food allergy, parental migration, self-identification as Black, and cesarean delivery.
- Factors like low birth weight, postterm birth, maternal diet, and stress during pregnancy showed no significant risk difference.
- The study highlights a combination of major and minor risk factors contributing to childhood food allergy development.