Probiotics for Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis With Trial Sequential Analysis - PubMed
5 hours ago
- #probiotics
- #irritable bowel syndrome
- #meta-analysis
- Probiotics show significant improvement in IBS Symptom Severity Score (IBS-SSS) but not in IBS Quality of Life (IBS-QOL).
- Trial Sequential Analysis (TSA) indicates current evidence is insufficient, recommending further high-powered trials.
- Majority of studies were of low risk of bias, but GRADE evaluation shows low certainty of evidence due to inconsistency.
- Future trials need standardization and efforts to identify sources of heterogeneity.