Kynurenic acid mediates epicardial fat-induced lymphatic metabolic dysfunction in atrial fibrillation - PubMed
6 hours ago
- #Metabolic Regulation
- #Atrial Fibrillation
- #Lymphatic Dysfunction
- Impaired atrial lymphangiogenesis is a critical determinant in atrial fibrillation pathogenesis.
- Epicardial adipose tissues from AF patients secrete kynurenic acid, which disrupts lymphatic endothelial cell metabolism via GPR35.
- Therapeutic interventions promoting lymphangiogenesis, such as VEGFC administration or weight loss, significantly reduce atrial fibrillation inducibility.