Evaluation of oncologic safety and clinical effectiveness of immediate autologous fat grafting in breast-conserving surgery: a multicenter, prospective, randomized controlled clinical trial for breast
2 months ago
- #autologous fat grafting
- #breast cancer
- #oncologic safety
- Study evaluates oncologic safety and clinical effectiveness of immediate autologous fat grafting (IAFG) in breast-conserving surgery (BCS) for breast cancer.
- Multicenter, prospective, randomized controlled trial with 360 women (2017-2021), comparing BCS with IAFG vs. BCS alone.
- Primary outcomes: locoregional and systemic recurrence rates; secondary outcomes: adverse events, patient satisfaction, psychosocial well-being.
- No significant difference in local relapse (0.6% IAFG vs. 2.4% control), distant recurrence (3.6% vs. 3.5%), or mortality (0.6% both).
- IAFG group showed higher satisfaction scores in breast appearance, psychosocial well-being, and sexual well-being compared to controls.
- Conclusion: IAFG is safe, does not increase recurrence risk, and improves patient satisfaction and psychosocial outcomes post-surgery.