STIM1-Mitofusin2 interactions tether mitochondria and melanosome contacts that promote melanosome maturation - PubMed
5 days ago
- #STIM1-MFN2
- #melanosome
- #mitochondria
- STIM1-Mitofusin2 interactions mediate mitochondria-melanosome contacts.
- Mitochondria-melanosome contacts increase during melanosome maturation.
- A NanoBiT-based reporter system, MiMSBiT, monitors these contacts in living cells.
- STIM1 localizes to melanosomes and promotes contact with mitochondrial MFN2.
- Decrease in melanosomal lumen calcium induces STIM1 clustering and enhances MFN2 association.
- Contacts increase mitochondrial ATP availability, leading to melanosome lumen acidification.
- Acidification facilitates PMEL fibrillation, a key step in melanosome maturation.
- The study reveals a mechanism regulating melanosome maturation via organelle contacts.