Candida albicans synergizes with Fusobacteriumnucleatum in colorectal cancer progression via the Flo9-RadD interaction - PubMed
6 hours ago
- #Fusobacterium nucleatum
- #Candida albicans
- #colorectal cancer
- Fusobacterium nucleatum tumor infiltration is a hallmark of colorectal cancer (CRC) progression.
- Candida albicans synergizes with F. nucleatum to promote CRC pathogenesis and contributes to poor patient outcomes.
- Co-inoculation of C. albicans and F. nucleatum accelerates CRC progression in animal models compared to either microbe alone.
- C. albicans strains from CRC patients show enhanced hyphal morphogenesis and elevated FLO9 expression, promoting F. nucleatum-mediated tumor growth.
- Mechanistically, the Flo9-RadD interaction facilitates F. nucleatum localization to the colonic mucosa and malignant transformation.
- L-arginine disrupts the C. albicans-F. nucleatum interaction, reducing their synergistic pro-tumor activity in CRC models.
- Fungal-bacterial interaction is a critical etiologic mechanism in CRC and a potential therapeutic target.