ACOD1 regulates microglial arginine metabolism and inflammatory responses - PubMed
18 hours ago
- #ACOD1
- #microglia
- #arginine metabolism
- Itaconate, synthesized by ACOD1 from cis-aconitate, acts as a negative feedback regulator of inflammation in macrophages.
- ACOD1-deficient microglia show stronger inflammatory responses to LPS, linked to increased ACLY activity and elevated acetyl-CoA.
- ACOD1 deficiency reprograms arginine metabolism, enhancing argininosuccinate synthesis while reducing polyamine biosynthesis.
- Inhibiting ACLY reverses the effects of ACOD1 deficiency on arginine metabolism, highlighting ACLY's role in this pathway.
- The study provides new insights into ACOD1's immunometabolic functions in microglia, connecting it to inflammatory regulation via metabolic shifts.