Resident tissue macrophages maintain intraocular pressure homeostasis - PubMed
14 hours ago
- #macrophages
- #intraocular pressure
- #glaucoma
- Resident tissue macrophages play a crucial role in maintaining intraocular pressure homeostasis.
- Macrophages in the conventional outflow tract have distinct origins and spatial organization across the mouse lifespan.
- Long-lived resident tissue macrophages are concentrated in the trabecular meshwork and Schlemm's canal.
- Depletion of resident tissue macrophages leads to increased intraocular pressure and outflow resistance due to aberrant extracellular matrix turnover.
- Monocyte-derived macrophages do not significantly impact intraocular pressure regulation when depleted.
- The study highlights the specific functions of macrophages based on their origin and location within the outflow tract.
- Dysfunction in resistance-generating tissues, where resident macrophages are active, is linked to glaucoma.