Amelioration of colitis through restored gut ecology using Christensenella intestinihominis AF73-05CM02 as a probiotic in mice - PubMed
4 hours ago
- #colitis
- #probiotic
- #gut-microbiome
- The study investigates the potential of Christensenella intestinihominis AF73-05CM02, a probiotic strain isolated from a Chinese individual, in treating colitis in mice.
- Inflammatory bowel disease (IBD), such as ulcerative colitis (UC), is associated with gut microbial imbalance, where C. intestinihominis is depleted in UC patients.
- Oral administration of AF73-05CM02 in a DSS-induced murine colitis model alleviates symptoms like weight loss, colonic injury, and improves intestinal health markers.
- The probiotic works by restoring gut ecology: reducing harmful bacteria (e.g., Helicobacter species), increasing beneficial taxa (e.g., Akkermansia), and enhancing intestinal epithelial barrier integrity.
- AF73-05CM02 also regulates immune responses and strengthens microbial network interactions that are disrupted in UC, suggesting its therapeutic potential for IBD treatment.