Immune-mediated side effects of cancer immunotherapies - PubMed
4 days ago
- #immunotherapy
- #side effects
- #cancer treatment
- Immunotherapies like allogeneic hematopoietic cell transplantation and CAR-T cells have expanded treatment options for hematological malignancies.
- Immune checkpoint inhibitors improve survival in solid tumors but come with immune-mediated side effects.
- Key immune-mediated side effects include GVHD, CRS, ICANS, IEC-HS, ICAHT, LICATS, and irAEs.
- Recent research highlights the role of myeloid cells and T-cells in the pathophysiology of these side effects.
- The review discusses current and potential future therapies for managing these immune-mediated toxicities.
- Understanding commonalities in side effects can help develop strategies to mitigate them.