The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice - PubMed
12 hours ago
- #S100A8/A9
- #cancer cachexia
- #energy balance
- Cancer cachexia is a wasting syndrome marked by reduced food intake and loss of lean and fat tissue.
- In mice, cancer cachexia led to significant reductions in host fat and lean mass, particularly skeletal muscle, balanced by tumor growth.
- 15N tracing revealed that the tumor derives protein (nitrogen) from both food intake and host tissue breakdown.
- Total energy expenditure remained unchanged due to metabolic compensation among the tumor, brown adipose tissue (BAT), and other organs, a phenomenon also seen in humans with cancer.
- The decrease in leptin due to fat loss did not stimulate food intake or reduce energy expenditure.
- S100A8/A9 and complement 3 (C3) in the hypothalamus play a key role in reducing food intake and fat mass during cancer cachexia.
- Peripheral administration of S100A8/A9 inhibitors and hypothalamic knockdown of C3 significantly increased food intake and partially rescued fat and lean tissue loss.