Proteomic characterization of intrahepatic cholangiocarcinoma identifies risk-stratifying subgroups and EIF4A1 as a therapeutic target - PubMed
5 hours ago
- #Proteomics
- #Cholangiocarcinoma
- #EIF4A1
- Proteomic analysis identifies two distinct intrahepatic cholangiocarcinoma (ICC) subgroups with different recurrence times.
- A 4-protein classifier effectively stratifies ICC patients into ECM-enriched (longer TTR) and proliferation (shorter TTR) clusters.
- EIF4A1 is identified as a therapeutic target, with its inhibition reducing tumor growth in PDX models.
- The study validates the prognostic relevance of proteomic clusters across independent datasets.
- Tumor-stroma interactions are highlighted as critical in ICC progression.