Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo-Controlled Clinical Trial of High Force Eccentric Contraction Rec
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- #nicotinamide
- Nicotinamide (NAM) and Pyridoxine (PN) supplementation enhances muscle stem cell (MuSC) activity and muscle regeneration in humans.
- A randomized, placebo-controlled clinical trial was conducted on healthy young men aged 18-49.
- Participants received daily doses of 714 mg NAM and 19 mg PN or placebo for 9 days post high-force eccentric muscle contractions.
- Primary endpoint: MuSC activity measured via immunohistofluorescence on biopsy sections from the vastus lateralis muscle.
- Secondary outcomes included histological markers of muscle regeneration and clinical markers of muscle damage.
- Results showed significant increases in Pax7, MyoD, and myogenin positive cells (+29%-67%) and regenerating fibers (+37%) in the NAM/PN group.
- NAM/PN supplementation was well-tolerated and increased blood concentrations of NAM and PN vitamers.
- Findings suggest therapeutic potential for muscle recovery and muscle wasting disorders.