Fecal immunochemical tests from population-based colorectal cancer screening programs support prospective microbiome cohorts - PubMed
4 hours ago
- #Fecal Immunochemical Test
- #Gut Microbiome
- #Colorectal Cancer
- Utilized residual FIT stool samples from a CRC screening program in Turin, Italy, for a large, population-based case-control study.
- DNA extraction and whole-genome shotgun sequencing were performed on samples from CRC, advanced adenomas, early adenomas, and FIT-negative controls.
- Alpha diversity was inversely associated with colorectal neoplasms, especially early adenomas (OR: 0.45, 95% CI: 0.25-0.80).
- Oral pathogens like Parvimonas micra, Escherichia coli, and Bacteroides fragilis were linked to higher odds of colorectal neoplasms.
- Supports CRC screening programs as a resource for prospective microbiome research on cancer risk in large populations.