Fisetin-loaded nanoparticles as a novel approach for cholesterol regulation in hypercholesterolemia: targeting the ASGR1-mediated mTORC1/AMPK pathway - PubMed
6 hours ago
- #fisetin
- #hypercholesterolemia
- #nanoparticles
- Fisetin-loaded nanoparticles show promise in regulating cholesterol levels in hypercholesterolemia.
- Fisetin significantly reduces hepatic steatosis, TC, TG, and LDL-C levels in hypercholesterolemic mice.
- The flavonoid fisetin modulates proteins involved in cholesterol excretion and metabolism, maintaining homeostasis.
- Fisetin targets ASGR1, influencing the mTORC1/AMPK-BRCA1/BARD1 pathway to lower cholesterol.
- CMCS-modified β-CD-based fisetin nanoparticles enhance bioavailability and efficacy at lower doses.
- The study suggests fisetin nanoparticles as an innovative therapeutic strategy for hypercholesterolemia.