Cigarette Smoke Exacerbates Pressure Overload-Induced Right Ventricular Dysfunction via ALOX15-Mediated Ferroptosis - PubMed
6 hours ago
- #ALOX15
- #COPD-PH
- #ferroptosis
- Cigarette smoke (CS) exacerbates right ventricular (RV) dysfunction in pressure overload conditions via ALOX15-mediated ferroptosis.
- A rat model of pulmonary artery banding (PAB) combined with CS exposure showed worsened RV function, hypertrophy, fibrosis, and capillary rarefaction.
- Transcriptomic analysis identified activation of the ALOX15-ferroptosis pathway in RV tissue from CS-exposed PAB rats.
- ALOX15 was predominantly localized in cardiomyocytes, and its inhibition reduced cardiac stress markers ANP and BNP.
- The study suggests ALOX15-mediated ferroptosis as a key mechanism and potential therapeutic target for RV dysfunction in COPD-PH.