Phase Separation of NFIB Suppresses SLC3A2-Mediated Ferroptosis in Castration-Resistant Prostate Cancer - PubMed
4 days ago
- #NFIB
- #CRPC
- #ferroptosis
- NFIB suppresses ferroptosis in castration-resistant prostate cancer (CRPC).
- NFIB upregulation in CRPC correlates with SLC3A2, a key subunit of System Xc-.
- NFIB knockout enhances erastin-induced ferroptosis, increasing Fe2+, MDA, and ROS levels.
- NFIB activates SLC3A2 transcription and forms nuclear condensates via disordered regions.
- SIRT7 regulates NFIB acetylation at K65, affecting condensate dynamics and ferroptosis sensitivity.
- K65 mutation reduces condensate liquidity and weakens SLC3A2 activation, promoting ferroptosis.
- Combined NFIB suppression and ferroptosis induction inhibits tumor growth in CRPC xenografts.