Mitochondrial lactate venting limits oxidative stress - PubMed
5 hours ago
- #lactate
- #oxidative stress
- #mitochondria
- Lactate enters mitochondria and promotes lactylation of mitochondrial proteins.
- Lactate crosses the inner mitochondrial membrane via a pathway partly sensitive to mitochondrial pyruvate carrier (MPC) inhibition.
- Lactate does not significantly energize the electron transport chain under tested conditions.
- Energized mitochondria can produce lactate from pyruvate, especially under hypoxia.
- Blocking MPC leads to matrix lactate and H₂O₂ accumulation, indicating a lactate-based 'vent' mechanism.
- This venting process helps modulate mitochondrial energy and reactive oxygen species levels.