Obesity, White Matter Hyperintensities, and Cognitive Decline: Sex-Specific DTI-ALPS Index Mediation - PubMed
6 hours ago
- #white matter hyperintensities
- #obesity
- #glymphatic system
- Study investigates sex-specific links between obesity, white matter hyperintensities, and cognitive decline, focusing on glymphatic system function via DTI-ALPS index.
- Finds central adiposity (waist-hip ratio) drives effects in males for deep WMH and glymphatic function, while general adiposity (BMI/body fat) mediates via DTI-ALPS index in females.
- Highlights the importance of sex-tailored interventions to protect glymphatic health and reduce brain injury risk.