Structural and Functional Diversity of Mitochondria Isolated from Different Cell Types - PubMed
4 days ago
- #bioenergetics
- #mitochondrial transplantation
- #mesenchymal stromal cells
- Mitochondria are crucial for energy production, autophagy, and apoptosis, with dysfunction linked to diseases.
- Mitochondrial transplantation is a promising therapy to restore cellular functions by boosting ATP and reducing oxidative stress.
- The study compared mitochondria from mesenchymal stromal, hepatic, muscular, and pluripotent stem cells to find the best source for transplantation.
- Mitochondria were isolated using a streptolysin O-based method and analyzed for size, zeta potential, protein, and ATP content.
- Mesenchymal stromal cell-derived mitochondria showed the highest bioenergetic activity, improving proliferation, oxygen consumption, and oxidative stress resistance in recipient cells.
- Findings suggest mesenchymal stromal cells are the optimal source for mitochondrial transplantation therapy.