Inflammatory arthritis irAE may represent a unique autoimmune disease primarily driven by T cells but likely not autoantibodies - PubMed
17 hours ago
- #T cells
- #inflammatory arthritis
- #autoimmunity
- Inflammatory arthritis (IA) as an immune-related adverse event (irAE) is primarily driven by T cells and likely not autoantibodies.
- IA-irAE shows increased cytotoxic gene expression and metabolic activation in T cells, with reduced CXCR3 and CCR6 expression in CD4+ T cells.
- Unlike seronegative rheumatoid arthritis (RA), IA-irAE patients have no substantial elevation in autoantibody levels or atypical CD11c+CD21- B cells.
- Elevated levels of interleukin-6 (IL-6), IL-12, and type I interferon in IA-irAE correlate with T cell activation phenotypes.
- IA-irAE is defined as a T cell-driven, autoantibody-independent autoimmune disease distinct from RA, offering insights into immune tolerance and therapy.