The stress responsive transcription factor ATF4: from molecular structure to disease mechanisms - PubMed
5 hours ago
- #Epigenetic modification
- #Post-translational modification
- #ATF4
- ATF4 is a transcription factor involved in cell survival and death regulation.
- It controls genes related to stress responses, autophagy, and metabolism.
- ATF4 levels are regulated by translational, epigenetic, and post-translational modifications.
- Epigenetic and PTM modifications fine-tune ATF4 activity and are linked to diseases like cancer and neurodegeneration.
- The review discusses ATF4's regulatory mechanisms and its role in disease progression, suggesting therapeutic targets.