[Occurrence Characteristics and Associated Factors of Alzheimer's Disease Drugs in Wastewater in China] - PubMed
5 hours ago
- #Alzheimer's disease
- #wastewater epidemiology
- #socioeconomic factors
- Study analyzes occurrence of Alzheimer's disease (AD) drugs in wastewater across 31 Chinese provinces.
- Four main AD drugs (donepezil, rivastigmine, galantamine, memantine) and their metabolites were detected in high rates (7.47-21.60 ng·L⁻¹).
- Regional differences in drug concentrations were observed, with variations across East, Northwest, Northeast, Southwest, and North China.
- AD drugs and metabolites with high detection and excretion rates were used as biomarkers to estimate AD prevalence via wastewater-based epidemiology.
- Estimated AD prevalence from wastewater data aligned with official statistics.
- Socioeconomic factors (stress, aging population, economic development, healthcare) showed significant positive correlation with AD prevalence and drug occurrence in wastewater.
- Findings support better understanding and control measures for AD drugs in wastewater treatment plants.