Linking peripheral low-grade inflammation and blood-cerebrospinal fluid barrier leakage in schizophrenia spectrum disorders - A retrospective analysis - PubMed
5 hours ago
- #inflammation
- #blood-cerebrospinal fluid barrier
- #schizophrenia
- Study links peripheral low-grade inflammation (pLGI) to blood-cerebrospinal fluid barrier (BCSFB) leakage in schizophrenia spectrum disorders.
- Retrospective analysis of 31 patients with schizophrenia or affective psychosis showed a positive correlation between BCSFB permeability and pLGI.
- The CSF/serum albumin ratio, indicating BCSFB permeability, correlated with pLGI score and age, with platelets being the main driver of pLGI's effect on BCSFB.
- A trend towards negative correlation between BCSFB permeability and global functioning (GAF) was observed, but no correlation with social isolation or PANSS6 scores.
- Findings suggest peripheral inflammation markers could be useful in diagnosing psychotic disorders, warranting further research.