NLRP14 modulates the activity of E3 ubiquitin ligases during the oocyte-to-embryo transition - PubMed
6 hours ago
- #Ubiquitination
- #NLRP14
- #Embryogenesis
- NLRP14 is essential for early embryonic development in mammals.
- It interacts with KDM2A and UHRF1 to regulate E3 ubiquitin ligase activity.
- NLRP14 inhibits SCF complex assembly and UHRF1 activity, preventing excessive ubiquitination.
- Deletion of NLRP14 leads to increased ubiquitination levels in oocytes and early embryos.
- This regulatory mechanism maintains proteostasis during the oocyte-to-embryo transition.
- Dysregulation of proteostasis may contribute to reproductive disorders.