SREBP2 links ACSS2-dependent acetyl-CoA biosynthesis to metaboloepigenetic activation of hepatic stellate cells and liver fibrosis - PubMed
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- #liver fibrosis
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- SREBP2 deletion in hepatic stellate cells (HSCs) or myofibroblasts reduces liver fibrosis in mice.
- SREBP2 activates ACSS2 transcription, which is necessary for acetyl-CoA production and histone acetylation.
- ACSS2 inhibition mitigates liver fibrosis, suggesting therapeutic potential for targeting this pathway.