Sleep disorders and sleep behaviors as predictors of neurodegenerative diseases - PubMed

5 hours ago

Sleep disorders (SDs) are associated with an increased risk of neurodegenerative diseases (NDDs), with a hazard ratio of 1.32.
The study included 30,032 participants with SDs and 147,321 without SDs from the UK Biobank cohort.
SDs were linked to higher NDD risk regardless of treatment status, and specific SD subtypes also showed increased risk.
Sleep behaviors like difficulty waking and daytime napping were associated with higher NDD risk in individuals with SDs.
Incorporating SD subtype variables improved the performance and clinical utility of NDD prediction models.
The findings highlight the potential of SDs and related behaviors as targets for early prevention strategies against NDDs.

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